Ottawa built a three-goal lead on a struggling Jhonas Enroth Tuesday night. The Sabres tried to rally, but fell short, losing 4-3.
Buffalo has now dropped seven of its last eight games
Erik Karlsson got the Senators on the board with a power play strike from the blue-line in the first period, but Tyler Ennis answered just 21 seconds later to tie the game at 1-1.
Enroth let Chris Phillips's shot trickle over his pads for a 2-1 Ottawa lead, then gave up another goal to Daniel Alfredsson to make it a 3-1 game after the first period.
Ottawa made it 4-1 on Chris Neil's goal, before the Sabres would respond. Jordan Leopold's first goal of the season cut the deficit back to two.
In the third period, Jason Pominville scored his sixth of the season - a goal that was originally waved off, before a review confirmed that Pominville did not intentionally kick the puck into the net.
Buffalo had a chance to tie it late in the game with a flurry of chances, but could not score the equalizer.
The Sabres have the day off from practice Wednesday, before hitting the ice at home against Montreal Thursday night.
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