Orchard Park Police received a 911 call reporting a pedestrian had been hit on Southwestern Boulevard near Abbott Road at 6:30 p.m.
Police tell News 4 the 52-year-old victim attempted to cross Southwestern when they were hit by a vehicle traveling east.
The victim was declared dead at the scene.
Investigators from both Orchard Park and West Seneca Police Department were on scene, and the investigation continues.
Police are not releasing the name of the victim at this time.
This story is developing, check back for updates.