Andrew Luck entered Sunday’s game against the Bills leading the league with 288 passing attempts.
He continued to toss it around on Sunday, throwing for 156 yards and four touchdowns in the Colts 37-5
Buffalo’s offense, which has struggled over the last few weeks, couldn’t match Indianapolis and received an even bigger blow just two plays into the game, losing star running back LeSean McCoy to a head injury.
Derek Anderson, who started in place of rookie Josh Allen due to an elbow injury, made his first start of the season and turned the ball over four times.
The veteran quarterback was intercepted three times and fumbled once, with three of the four urnovers leading to points for the Colts. Tight end Charles Clay also fumbled, which the Colts capitalized to take a 14-0 lead.
Driving down the field near the end of the first half, Anderson was picked off trying to connect with Kelvin Benjamin. The Colts returned the ball it to the 32 yard line before Adam Vinatieri’s 36-yard field goal to give Indianapolis a 24-0 lead at half.
Anderson and the Bills offense strung together their best drive of the day to open the second half, marching 12-plays into Colts territory. Stephen Hauschka got the Bills on the board with a 34-yard boot.
After a bad snap led to a safety, trailing 24-5, Buffalo had a chance to continue to chip away at the Colts’ lead. However, Anderson was hit from behind while dropping back and fumbled, setting Indianapolis up with 1st-and-goal inside the five yard line.
Luck would ultimately connect with T.Y. Hilton for the second time to pull ahead 31-5.
It wasn’t just the pass defense that struggled on Sunday for Buffalo. The defense was also gashed on the ground, giving up 220 yards, including 126 from Marlon Mack.
They also struggled to get pass rush, failing to record a sack for the first time this season. The defense sacked DeShaun Watson seven times in their 20-13 loss in Week 7.
With the loss, Buffalo drops to 2-5 ahead of their showdown with the Patriots on Monday Night Football.